B016324 - ORGANIC CHEMISTRY

Italian

Introduction on the chemical bond and the concept of molecular orbital. Nomenclature, structure and reactivity of the main functional groups and the various classes of organic compounds, their conformational analysis and stereochemistry. At the end, the structure and the properties of the main classes of biologically relevant organic compounds, i.e. sugars, amino acids and peptides, as well as fats, will be dealt with.

B. Botta, a cura di, Chimica Organica Essenziale, Edi-Ermes 2012

W. H. Brown, Introduzione alla Chimica Organica, VI Edizione, EdiSES

Upon completion of this class, students will be able to predict bonding and three-dimensional structure, including chirality of organic compounds. Students will be able to predict the reactivity of specific functional groups, and construct efficient, simple mechanistic pathways for the synthesis of a given compound.

Frontal lessons and exercises

The exam consists of a mandatory written and an oral (on request) aimed at verifying the ability to assign the name to an organic compound, analyze it from a conformational and stereochemical point of view and evaluate its properties and reactivity. The exam is also aimed at evaluating the student's knowledge on molecules of biological interest (amino acids, sugars, fats and nucleic acids) treated during the course. The written exam lasts 60 minutes and consists of 7 open questions relating to the various topics covered during the course. Students who pass the written exam will be admitted to the on request oral exam, in which the exam topics will be further explored for a better evaluation of the students' knowledge and ability to apply them.

The chemical bond, resonance, VSEPR model, ionic and covalent bond, molecular orbitals, ibridization. Methane, ethane, ethylene, acetylene. Brøensted-Lowry’s acids and bases, nucleophiles and electrophiles. The names of organic compounds. Stereochemistry, enantiomers and diastereomers, optical rotation. Alkanes, synthesis and reactivity, conformational analysis. Cycloalkanes, properties and conformational analysis of cycloalkanes. Alkenes, synthesis and reactivity, addition, oxidation, reduction, polymerization. Alkyl halides, nucleophilic substitution. Alcohols, synthesis and reactivity, oxidation. Ethers and epoxides. Amines, synthesis and reactivity. Aldehydes and ketones, synthesis and reactivity, addition of various nucleophiles. Aldol condensation. Organometallic reagents. Carboxylic acids and their derivatives, acyl chlorides, anhydrides, esters and amides, synthesis and reactivity. Aromatic compounds, aromatic electrophilic substitution. Heteroaromatic compounds. Lipids, sugars, amino acids and peptides.

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4. Quality education
5. gendere equality